センソモーター体験は,視界入力をコース・ディレクション・ネットワークにマップします
Yvette E Fisher1, Jenny Lu1, Isabel D'Alessandro1
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Nature
|November 22, 2019
まとめ
フルーツ・フライの使用
科学分野:
- 神経科学
- 動物 の 行動
背景:
- ドロソフィラのコンパスニューロンは 自律的な動きを統合して 方向を推定します
- Rニューロンがインプットを媒介する 視覚的なヒントは方向の精度を高めます
- コンパスネットワークに視覚的なシグナルを統合するメカニズムは不明です.
研究 の 目的:
- ドロソフィラのコンパスニューロンネットワークに 視覚信号がどのように統合されているかを調べます
- Rニューロンがコンパスニューロンに視覚入力を媒介する役割を決定する.
- コンパスシステムの視覚処理の可塑性を明らかにする.
主な方法:
- ドロソフィラの体内全細胞記録
- カルシウム画像を集めました
- 仮想現実環境の探索
主要な成果:
- 視覚信号はコンパスニューロンのシナプス阻害を誘発し Rニューロンによって媒介されます
- コンパスニューロンは 特定の視覚的な位置感を示します
- 視覚的に誘発された阻害パターンは 環境の変化で再編成され コンパスの座標枠が変化します
結論:
- 視覚的に誘発された阻害の関連性のある長期的なシナプス抑制が,可塑性の基礎です.
- この可塑性は 方向性のある自己運動と 外部からのシグナルを 調和させています
- 発見は,ナビゲーションのためのアトラクターダイナミクスと組み合わせた,アソシエティブな可塑性のモデルをサポートします.
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