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Updated: Jan 3, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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機能強化剤 形状 染色体外腫瘍遺伝子の増幅

Andrew R Morton1, Nergiz Dogan-Artun2, Zachary J Faber1

  • 1Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, OH 44106, USA.

Cell
|November 26, 2019
PubMed
まとめ

ガン遺伝子の増幅はしばしば,非コーディングDNA,特にEGFRのような腫瘍遺伝子の近くの増強剤を含みます. 細胞の健康に不可欠なこれらの領域は,グリオブラストーマの染色体外DNAで維持されます.

キーワード:
EGFRMYC についてMYCN についてダブル・ミニット強化剤エピジェネティック染色体外DNAグリオブラストーマ腫瘍遺伝子の増幅

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