関連する実験動画

Updated: Jan 3, 2026

Quantification of Atherosclerosis in Mice
06:59

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Published on: June 12, 2019

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GPR146欠乏症 高コレステロール血症と動脈硬化症から保護する

Haojie Yu1, Antoine Rimbert2, Alice E Palmer3

  • 1Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, MA 02215, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

Cell
|November 29, 2019
PubMed
まとめ

孤児Gタンパク質結合受容体146 (GPR146) は,ERK経路を活性化して,非常に低密度の脂質タンパク質分泌に影響を与え,コレステロール代謝を調節する. GPR146の抑制は血コレステロールを大幅に低下させ,動脈硬化症を減少させます.

キーワード:
ERK1/2SREBP2経路について動脈硬化症高コレステロール血症孤児Gタンパク質結合受容体

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