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このページは機械翻訳されています。他のページは英語で表示される場合があります。View in English
  1. ホーム
  3. 研究分野
  5. 生物医学と臨床科学
  7. 心血管医学と血液学
  9. 心臓病 (心血管疾患を含む)
  11. 冠動脈微小血管機能障害,左心室改造,慢性腎不全患者の臨床結果

冠動脈微小血管機能障害,左心室改造,慢性腎不全患者の臨床結果

Navkaranbir S Bajaj1,2, Amitoj Singh1, Wunan Zhou1

  • 1Cardiovascular Imaging Program, Departments of Radiology and Medicine; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology; and Divisions of Cardiovascular Medicine and Nephrology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (N.S.B., A.S., W.Z., A.G., K.F., C.B., H.J.H., P.B., E.A., S.D., C.F.B., J.H., H.S., V.T., M.S., S.D., R.B., R.C.D., S.D.S., M.F.D.C.).

Circulation
|November 30, 2019

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PubMed で要約を見る

まとめ
この要約は機械生成です。

腎臓機能ではなく冠動脈微小血管機能障害は 明らかに冠動脈疾患のない患者の心臓疾患を 独立して予測します この機能障害は腎臓疾患と心臓の障害,心血管疾患と関連付けられる.

科学分野:

  • 心臓病科
  • 腎臓科
  • 心血管イメージング

背景:

  • 慢性腎臓病 (CKD) の患者は,閉塞性冠動脈疾患がない場合でも,しばしば心機能障害や心血管疾患を経験します.
  • 慢性腎臓病と心機能障害と有害な結果を結びつける根本的なメカニズムは不明である.
  • 冠動脈微小血管機能障害 (CMD) は,腎機能障害と心臓の問題との関係を橋渡しすると仮定されています.

研究 の 目的:

  • CKD,CMD,心臓機能障害,心血管疾患との関連を調査する.
  • 明らかに冠動脈疾患のない患者のCKDと不良心血管疾患との関連をCMDが媒介するかどうかを判断する.

主な方法:

  • 心臓のストレスポジトロン放出トモグラフィー (PET) とエコーカーディオグラフィーを受けた352人の患者の長期研究.
  • 推定グルメルフィルタレーション率 (eGFR) によって評価された腎機能.
  • PETで測定された冠動脈流量準備量 (CFR); 心臓のメカニズムがエコーカルディオグラフィで評価された (ダイアストリックおよびシストリック指標).
  • 死亡,心筋梗塞,心不全の入院の複合的なアウトカムについて,患者さんを追跡した.
  • 統計分析には多変量モデルとメディエーション分析が含まれていた.

主要な成果:

キーワード:
慢性的な腎不全 腎不全

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  • 患者の35%はEGFR < 60mL·min−1. 73m−2であり,CFRの中央値は1. 8であった.
  • eGFRとCFRは,心臓のメカニズムと心血管疾患に関連していた (P<0. 05).
  • 多変量モデルでは,CFRは,eGFRは,独立して心臓のメカニズムと心血管事件と関連していました.
  • eGFR,心臓のメカニズム,および心血管イベントの関係は,部分的にCFRによって媒介された.

    • 結論:

    • 冠動脈微小血管機能障害は,eGFR単独ではなく,異常な心力学と心血管疾患のリスクの増加と独立して関連しています.
    • 明らかに冠動脈疾患のない患者では,CKDを心機能障害と不良心血管の結果と結びつける重要な媒介として機能する.