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Deciphering Molecular Mechanism of Histone Assembly by DNA Curtain Technique
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人間のコヘシンはループエクストルーションでDNAを圧縮する

Yoori Kim1, Zhubing Shi1, Hongshan Zhang2

  • 1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Science (New York, N.Y.)
|November 30, 2019
PubMed
まとめ

Cohesin-NIPBLは,ATP駆動の分子マシンとして作用し,ループを挤出することでDNAを圧縮します. このプロセスはゲノム組織にとって不可欠であり,ATPの水解を必要とします.

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