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関連する概念動画

SNAREs and Membrane Fusion01:43

SNAREs and Membrane Fusion

12.2K
Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
12.2K
ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

6.8K
Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
6.8K
Polymers02:34

Polymers

40.1K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
40.1K
Polymers02:34

Polymers

23.1K
23.1K
Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

16.4K
Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
16.4K
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

2.7K
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
2.7K

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Updated: Jan 2, 2026

Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
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Forming Giant-sized Polymersomes Using Gel-assisted Rehydration

Published on: May 26, 2016

9.8K

ポリメリゼーション誘発型ポリマソーム融合

Spyridon Varlas1, Robert Keogh1, Yujie Xie1,2

  • 1School of Chemistry , University of Birmingham , Edgbaston , Birmingham B15 2TT , United Kingdom.

Journal of the American Chemical Society
|November 30, 2019
PubMed
まとめ
この要約は機械生成です。

人工ポリマーソームは,ポリメリゼーションによって誘発される外部の力なしに自発的に溶融し,管状の構造を形成します. このポリメリゼーション誘発型ポリマソーム融合は,薬物投与および触媒における応用のために,ナノ粒子の形状と組成を制御することを可能にします.

さらに関連する動画

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
10:58

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

Published on: August 24, 2016

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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.3K

関連する実験動画

Last Updated: Jan 2, 2026

Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
08:45

Forming Giant-sized Polymersomes Using Gel-assisted Rehydration

Published on: May 26, 2016

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SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy
10:58

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

Published on: August 24, 2016

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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.3K

科学分野:

  • ポリマー化学
  • 材料科学
  • バイオ物理学

背景:

  • 細胞間のコミュニケーションには 膜融合と分裂が不可欠です
  • 人工ポリマーソームは通常,外部の力場を必要とします.
  • 自己組み立てメカニズムを理解することは 先進的なナノマテリアルの鍵です

研究 の 目的:

  • 外部の力なしに融合促進された管状ポリマーソーム (チューベソーム) の形成を達成する.
  • ポリメリゼーション誘発のポリマソーム融合のメカニズムを探求する.
  • 管の形状と組成を制御する.

主な方法:

  • 水性環開きメタテシスポリメリゼーション誘発自己組立 (ROMPISA)
  • 異なるコアブロックのポリメリゼーション度 (DPs).
  • フォースター共振エネルギー転送 (FRET) と融合確認のためのコンフォカル顕微鏡.

主要な成果:

  • ROMPISA中に自発的にアニゾトロプ的チューボソームを形成する.
  • DPを調整することでチューボソームの構成と長さの分布を制御する.
  • ステップ・グロース・キネティクス,FRET膜混合,およびルメン混合による融合の証拠.

結論:

  • ポリメリゼーション誘発型ポリマソーム融合は,ポリマー鎖の緊張が増加することで引き起こされる新しいメカニズムである.
  • この方法は,球形および管状のポリマーソームの複製可能で調節可能な混合物への簡単な経路を提供します.
  • 制御された形態とコンパートメントの混合により,触媒,取引,および薬物投与における潜在的な応用.