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RNA Structure01:23

RNA Structure

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Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
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RNA Structure01:19

RNA Structure

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The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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RNA Secondary Structure Prediction Using High-throughput SHAPE
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乱れた単一鎖RNAの視覚化: 配列,構造,および静電性を接続する

Alex Plumridge1, Kurt Andresen2, Lois Pollack1

  • 1School of Applied and Engineering Physics , Cornell University , Ithaca , New York 14853 , United States.

Journal of the American Chemical Society
|December 6, 2019
PubMed
まとめ
この要約は機械生成です。

U と A トラクタのような単鎖RNAホモポリマーは,異なる構造とイオン大気を表しています. これらの配列に依存する性質はRNAの折りたたみとタンパク質の相互作用に影響します.

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Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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科学分野:

  • 生物化学
  • 分子生物学
  • バイオ物理学

背景:

  • 機能的な単一鎖RNA (ssRNA) のホモポリマー領域 (UまたはA領域など) は,分子構造とパートナー認識に不可欠である.
  • これらのssRNAモチーフの正確な形状および生体物理的性質は,まだ完全に理解されていません.

研究 の 目的:

  • 生物学的に有意なssRNAホモポリマーの形状とイオン大気を調査する.
  • ssRNAにおけるUとA経路の生体物理的特性を定量的に測定する.

主な方法:

  • ssRNAの構造を調べるために複数の実験技術を適用する.
  • ssRNAホモポリマーを取り巻くイオン大気の定量測定

主要な成果:

  • ssRNAの形状は配列に依存し,ユニークなイオン大気を引き寄せます.
  • ポリU (rU) 鎖は一般的に構造化されていないが,ポリA (rA) 鎖は,溶液条件によって影響を受け,スタッキングまたはクラスタリングによる順序付けを示している.
  • 観測された構造的差異は,イオン組成と大気の測定された差異と相関しています.

結論:

  • RNA 塩基,イオン,ssRNA 配列の間の複雑な相互作用が存在する.
  • ssRNAホモポリマーの独特の構造とイオンシグネチャーは,RNAの折りたたみとタンパク質認識におけるその役割を説明する.