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Updated: Jan 2, 2026

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates
06:00

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates

Published on: January 15, 2018

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アミドとニトリルのシュミット型形成における窒素ドナーとしてのニトロメタン

Jianzhong Liu1, Cheng Zhang1, Ziyao Zhang1

  • 1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Science (New York, N.Y.)
|December 7, 2019
PubMed
まとめ

研究者たちは危険なアジドではなく ニトロメタンを用いて より安全なシュミットのような反応を開発しました この新しい方法は,アルキンやアルキルベンゼンを含む様々な原料からアミドとニトリルを効率的に生成します.

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One of the common methods to prepare nitriles is the dehydration of amides. This method requires strong dehydrating agents like phosphorous pentoxide or boiling acetic anhydride for converting amides to nitriles. Another reagent namely, thionyl chloride also accomplishes the dehydration of amides, where amide acts as a nucleophile. The first step of the mechanism involves the nucleophilic attack by the amide on the thionyl chloride to form an intermediate. In the next step, the electron pairs...
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Amides can be reduced to primary, secondary, and tertiary amines using catalytic hydrogenation, active metals like Fe,...
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