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ウィルムズ腫瘍の胚前駆体
Tim H H Coorens1, Taryn D Treger1,2,3, Reem Al-Saadi4,5
1Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
Science (New York, N.Y.)
|December 7, 2019
まとめ
子どもの腎臓がん ウィルムズ腫瘍は 腎臓の正常な組織における 結核前のクローン増殖から発症することがあります 共通変異によって識別されるこれらの拡大は腫瘍形成に先行し,胚の発達初期に発生する可能性があります.
科学分野:
- 発達生物学
- 癌の研究
- 遺伝学
背景:
- 大人の癌はしばしば悪性前クローンの膨張から生じる.
- 幼児期の腫瘍,特にウィルムズ腫瘍の発達の起源は,大部分が特徴づけられていない.
- 早期発見と予防戦略において 癌前発症の原因を理解することは 極めて重要です
研究 の 目的:
- ウィルムスの腫瘍における前悪性クローン拡大の存在と特徴を調査する.
- ウィルムスの腫瘍が 発症前の背景から 発生したかどうかを判断する
- ウィルムスの腫瘍形成に寄与する初期発達の出来事を明らかにする.
主な方法:
- 腫瘍と正常な腎臓組織における体質変異を血液と比較して分析する.
- エピジェネティック・モディフィケーションの分析,特にH19ロカス・ハイパーメチレーション
- 双方の腫瘍を検査して クローン進化のタイミングを把握する
主要な成果:
- 研究された23例のウィルムズ腫瘍の61%で前悪性クローン拡大が確認された.
- これらの拡大は,共通の体内変異によって定義され,腫瘍発達の前の形態学的に正常な腎臓組織で発見されました.
- 既知のウィルムズ腫瘍の誘発因子であるH19の超メチル化は,これらのクローン拡大の58%で観察された.
結論:
- ウィルムズ腫瘍は,腎臓から発生した悪性前クローン拡張から発症する.
- これらのクローン膨張は胚形成の初期に発生し,腎臓の原始性の分岐に先立ちます.
- 発見は,片側および多焦点のウィルムズ腫瘍の発達に関与する重要な胚前駆体を示しています.
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