腸を神経化するノシセプターニューロンは,ペイヤーのパッチマイクロフォールド細胞とSFBレベルを調節し,サルモネラ宿主防御を媒介する
Nicole Y Lai1, Melissa A Musser2, Felipe A Pinho-Ribeiro1
1Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Cell
|December 10, 2019
まとめ
痛みを検知するノシセプター神経は サルモネラ菌の感染から 腸を防衛します これらのニューロンは 腸内微生物と特殊な細胞を制御し 病原体の侵入と拡散を制限します
科学分野:
- 神経科学
- 免疫学
- 微生物学
背景:
- 消化器の感覚神経は 有害な刺激に対して 保護的な反応を起こす
- 腸内感染症におけるこれらのニューロンの役割はほとんど不明である.
研究 の 目的:
- サルモネラ・エンテリカ・セロバル・タイフィムリウム (STm) 感染に対する宿主防御におけるノシセプターニューロンの役割を調査する.
主な方法:
- STmの植民地化,侵入,拡散に対する背骨の根のガンジーノシセプターの効果を研究した.
- マイクロフォールド (M) 細胞とセグメント状糸状細菌 (SFB) のノシセプターによる調節を分析した.
- TRPV1+ノシセプターのSTmへの反応とカルシトニン遺伝子関連ペプチド (CGRP) の放出を調査した.
主要な成果:
- ノシセプターニューロンは,STmに対する宿主防御を決定的に媒介する.
- ノシセプターは,ペイヤー・パッチの毛細部に関連する上皮質のM細胞密度を調節し,STmの侵入を制限する.
- ノシセプターはSFBレベルを維持し,STm感染に耐性を与える.
- TRPV1+ノシセプターはSTmに反応してCGRPを放出し,M細胞とSFBを調節する.
結論:
- ノシセプターの感覚神経は,STmのような腸内病原体に対する感知と防御に重要な役割を果たします.
- これらの発見は 神経系と腸内微生物を含む 宿主防御の新たなメカニズムを明らかにしています
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