妊活治療と子供のがんリスクとの関連
Marie Hargreave1, Allan Jensen1, Merete Kjær Hansen2
1Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
JAMA
|December 11, 2019
まとめ
凍結胚移植は,白血病や共感神経系腫瘍を含む小児がんのリスクがわずかに高まっている. 他の不妊治療は,この研究で有意ながん関連性を示さなかった.
科学分野:
- 生殖医学
- 小児腫瘍学
- 流行病学
背景:
- 世界中で 不妊治療で生まれた子供の数が増えています
- これらの治療が子供のがんリスクに与える影響は不明である.
- アソシエーションは特定の薬,処置,または不妊症と関連している可能性があります.
研究 の 目的:
- 様々な不妊治療と 子どものがんのリスクとの関連を調べる
- 特定の不妊薬と助産生殖技術に関連したリスクを区別する.
主な方法:
- デンマークの登録データを用いた遡及コホート研究 (1996年から2012年の出生,1996年から2015年のフォローアップ).
- 癌と診断された2217人
- 妊産薬と助産生殖技術 (ART) の母親の使用を分析し,結果と生育可能な女性から生まれた子供とを比較した.
主要な成果:
- 凍結胚移植 (FET) は,小児がんのリスクの増加と関連していた (HR,2. 43).
- FETによるリスク増加は主に白血病と交感神経系腫瘍に関連していた.
- 不妊薬や他のART方法を含む他の不妊治療では統計的に有意な関連性が見つかりませんでした.
結論:
- 凍結胚移植 (FET) の使用は,小児がんのリスクが小さく,統計的に有意に増加している.
- この研究で検討された他の不妊治療とこの関連性は観察されなかった.
- FETと癌の関連性を理解するには,さらなる研究が必要である.
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