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プラズマ膜V-ATPaseは,腫瘍性RAS誘発のマクロピノサイトーシスを制御する

Craig Ramirez1, Andrew D Hauser1, Emily A Vucic1

  • 1Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.

Nature
|December 13, 2019
PubMed
まとめ

腫瘍性RASは,真空 ATPase (V-ATPase) を移転することによって,栄養素吸収過程であるマクロピノサイトーシスを活性化します. この発見は,RAS変異性腫瘍とその代謝依存症を標的とする新しい経路を示しています.

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