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Updated: Jan 2, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
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Published on: August 29, 2015

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KRAS4Aはヘクソキナーゼ1を直接調節する

Caroline R Amendola1, James P Mahaffey1, Seth J Parker1

  • 1Perlmutter Cancer Center, NYU School of Medicine, New York, NY, USA.

Nature
|December 13, 2019
PubMed
まとめ

KRAS4Aはヘクソキナーゼ1 (HK1) と直接相互作用し,その活性が変化する. この新しいKRAS4A-HK1相互作用は,KRASシグナル伝達と細胞代謝の間の直接的なリンクを明らかにし,がんにおける潜在的な治療目標を提供します.

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