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RIPK1の非切除可能な変異によって引き起こされる支配的な自己炎症性疾患

Panfeng Tao1, Jinqiao Sun2, Zheming Wu3

  • 1The MOE Key Laboratory of Biosystems Homeostasis & Protection, Life Sciences Institute, Zhejiang University, Hangzhou, China.

Nature
|December 13, 2019
PubMed
まとめ

カスパース8分裂を阻害するRIPK1 (受容体相互作用タンパク質キナーゼ1) の遺伝子変異は,自己炎症性疾患を引き起こす. これは,RIPK1の活性化,細胞死に対する過敏性,および炎症反応の増大につながる.

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