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Updated: Jan 2, 2026

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
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RIPK1のカスパース分裂を防ぐ変異は,自己炎症性疾患を引き起こす

Najoua Lalaoui1,2, Steven E Boyden3, Hirotsugu Oda4

  • 1The Walter and Eliza Hall Institute, Parkville, Victoria, Australia. lalaoui@wehi.edu.au.

Nature
|December 13, 2019
PubMed
まとめ

RIPK1 (受容体相互作用タンパク質キナーゼ1) のカスパース8分裂は,胚の発達と自己炎症症症候群の予防に不可欠です. この分裂を防ぐ突然変異は,ヒトでは重度の炎症性疾患,マウスでは胚性致死を引き起こす.

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