関連する実験動画

Updated: Jan 2, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

腫瘍内ニッチは,幹細胞のようなCD8 T細胞を維持し,分化させます

Caroline S Jansen¹, Nataliya Prokhnevska¹, Viraj A Master^1,2

¹Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.

|December 13, 2019

まとめ

腫瘍に浸透するリンパ球 (TILs) は,がん生存と免疫療法への反応に不可欠です. この研究は,腫瘍内の幹細胞のようなCD8T細胞がエフェクタ細胞の形成を促し,効果的な抗がん反応のために特定の免疫ニッチを必要とすることを示しています.

科学分野:

免疫学
癌生物学
T細胞生物学

背景:

腫瘍浸透性リンパ球 (TILs) は,様々ながんにおける生存率と免疫療法の有効性の改善と相関しています.
腫瘍における異なるCD8T細胞の浸透を制御するメカニズムは完全に理解されていません.

研究の目的:

人間の癌における持続的なCD8T細胞応答の必要性を調査する.
CD8 T細胞が腫瘍に浸透する要因を特定する.

主な方法:

腫瘍内の異なるCD8T細胞群の分析
CD8 T細胞の分化と増殖のダイナミクスの調査.
T細胞浸透を支援する抗原呈現細胞 (APC) の役割の検討.

主要な成果:

腫瘍のCD8T細胞は,末端に微分化され,幹細胞のような個体群を構成する.
幹型のCD8T細胞は増殖時にエフェクタ子細胞を生成し,腫瘍の浸透に不可欠である.
幹細胞のようなCD8T細胞は,広範囲のT細胞浸透に不可欠な,密度の高いAPCニッチに局所されています.
病気が進行する患者はこれらの免疫ニッチが欠けている.

結論:

幹細胞のようなCD8T細胞がエフェクタ細胞に分化することは,抗腫瘍免疫に不可欠である.
APCが豊富な免疫ニッチの存在は,重要なT細胞腫瘍の浸透の前提条件です.
これらの免疫ニッチの崩壊は,進行する癌の免疫脱出のメカニズムを表す可能性があります.

さらに関連する動画

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

関連する概念動画

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Multipotency and Niche of Bulge Stem Cell

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...