関連する実験動画

Updated: Jan 2, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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p27は,サイクリン依存キナーゼ4をアロステリックに活性化し,パルボシクリブ抑制を逆行させる

Keelan Z Guiley1,2, Jack W Stevenson2, Kevin Lou2

  • 1Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.

Science (New York, N.Y.)
|December 14, 2019
PubMed
まとめ

リン酸化p27タンパク質はCDK4を活性化し,細胞増殖を促進する. この活性化された複合体は,非活性CDK4/ 6を標的とする薬剤パルボシクリブに耐性を持ち,がんにおける新たなメカニズムを明らかにしています.

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