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Updated: Jan 1, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

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ディアシルフロキサンは,GPX4を共性的に阻害するマスクされたニトリル酸化物である

John K Eaton1, Richard A Ruberto1, Anneke Kramm1

  • 1Broad Institute of MIT and Harvard , Cambridge , Massachusetts 02142 , United States.

Journal of the American Chemical Society
|December 17, 2019
PubMed
まとめ

ディアシルフロキサンは,グルタチオン過酸化酵素4 (GPX4) を共性的に阻害する. この発見は,薬剤耐性がんにおける重要なタンパク質であるGPX4を標的とする新しいメカニズムを提供し,治療の選択肢を広げています.

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