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Updated: Jan 1, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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トランポゾンでコードされたCRISPR-CasシステムによるDNAターゲティングの構造的基礎

Tyler S Halpin-Healy1, Sanne E Klompe1, Samuel H Sternberg2

  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.

Nature
|December 20, 2019
PubMed
まとめ

バクテリアのCRISPR-Casシステムは,DNAのトランスポーゼーションに再利用され,TniQ-カスケード複合のコラボレーションを伴う. 構造的な洞察は この複合体が DNAを標的とし 挿入を容易にし ゲノム工学の応用への道を開くことを明らかにします

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