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Updated: Jan 1, 2026

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model
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Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model

Published on: October 20, 2023

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アンジェルマン症候群のヒトの神経モデルにおけるカリウムチャネル機能障害

Alfred Xuyang Sun1,2, Qiang Yuan3,4, Masahiro Fukuda4

  • 1National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. sunxya@gis.a-star.edu.sg shawn.je@duke-nus.edu.sg.

Science (New York, N.Y.)
|December 21, 2019
PubMed
まとめ

アンジェルマン症候群 (AS) は,UBE3A遺伝子の障害を伴う. 研究者らは,大きなカリウム (BK) チャンネルをターゲットにすることで,ASモデルにおけるニューロンの過興奮性と発作を軽減でき,潜在的な治療戦略を提供できることを発見しました.

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