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Updated: Dec 31, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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パラヘルクアミド生物合成経路におけるスパイロサイクル形成の分子基礎

Amy E Fraley, Kersti Caddell Haatveit1, Ying Ye

  • 1Department of Chemistry and Biochemistry , University of California , Los Angeles , California 90095 , United States.

Journal of the American Chemical Society
|January 7, 2020
PubMed
まとめ

研究者らは,フラビン一酸化酵素PhqKによって触媒化されたパラヘルクアミド生物合成の鍵となるスピロサイクリングステップを明らかにした. この研究により,PhqKが有力な殺虫剤の作用に不可欠な複雑な構造を選択的に形成していることが明らかになりました.

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