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卵巣がんのリスクと生殖器の粉末の使用の関連
Katie M O'Brien1, Shelley S Tworoger2,3, Holly R Harris4,5
1Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
JAMA
|January 8, 2020
まとめ
大規模な研究では,生殖器粉末の使用は卵巣がんのリスクと有意に関連していません. わずかなリスク増加を排除するには,さらなる研究が必要である.
科学分野:
- 婦人科腫瘍学
- 流行病学
- 公衆衛生
背景:
- 生殖器粉末の使用と卵巣がんとの関連は不明である.
- 以前の症例対照研究では,陽性な関連が示唆されましたが,コホート研究はこれを確認していません.
- この関係を明確にするには将来的なデータが必要です.
研究 の 目的:
- 生殖器粉末の使用と卵巣がんのリスクとの関連を調査する.
- 米国の大規模なコホートからの見通し観測データを利用して,堅実な分析を行う.
主な方法:
- 米国の4つの大きなコホート:看護師の健康研究,看護師の健康研究II,姉妹研究,女性の健康イニシアチブの観察研究から集められたデータです.
- 生殖器粉末の常用,長期 (≥20年),頻繁 (≥1週間) の使用を評価した.
- 同変数調整された危険比率 (HRs) と95%信頼区間 (CI) を推定するためにコックスの比例的危険モデルを使用した.
主要な成果:
- 分析対象は252,745人の女性で,38%が生殖器粉を使用したと報告した.
- 生殖器粉末と卵巣がんの間の統計的に有意な関連性は見つかりませんでした (HR,1. 8; 95% CI,0. 99-1. 17).
- 小さいリスクを検出する能力が研究に欠けても,頻繁にまたは長期にわたって使用する際の有意な関連は観察されなかった.
結論:
- この大規模な総合分析では,生殖器粉末の使用と卵巣がんとの間に統計的に有意な関連性が見出されなかった.
- リスクの小さな増加を検出するには,研究が不足している可能性があります.
- 関連性を明らかにするためにさらなる調査が必要である.
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