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関連する概念動画

Gastrulation01:56

Gastrulation

65.3K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
65.3K
Neurulation01:30

Neurulation

44.8K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
44.8K
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

3.7K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
3.7K
Cleavage and Blastulation01:33

Cleavage and Blastulation

49.5K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
49.5K

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Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
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中線軸に沿ってプログラムされた細胞死 胃化のipsilaterality

Lisandro Maya-Ramos1, Takashi Mikawa2

  • 1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.

Science (New York, N.Y.)
|January 11, 2020
PubMed
まとめ

細胞の対称性は 細胞の側に保たれています 細胞外マトリックスと胚のミッドラインでプログラムされた細胞死は,細胞の交差を防止し,イプシラテラルな発達を保証します.

科学分野:

  • 発達生物学
  • 進化生物学
  • 細胞生物学

背景:

  • 双面的対称性とは 主要な動物の体型で,左側と右側が通常分離している.
  • この保存されたボディプランをプログラムする正確なメカニズムは,特に初期の開発では,完全に理解されていません.

研究 の 目的:

  • 鳥類のガストルレーションで 胚層のパターンがどのように ipsilaterality を達成するかを調査する.
  • 逆側細胞の侵入を抑制し,胚のミドルラインを維持する要因を特定する.

主な方法:

  • 細胞の移動とパターンを観察するために 鳥の胃を研究した.
  • 操作された細胞外マトリックス (ECM) と プログラムされた細胞死 (PCD) が 胚のミッドラインに存在します
  • これらの操作がipsilateral gastrulationに与える影響を評価した.

主要な成果:

  • 侵入性細胞行動にもかかわらず,鳥類のガストルレーションにおける細菌層のパターンはipsilateralである.
  • 細胞外マトリックス (ECM) と中線でのプログラム細胞死 (PCD) は,対側細胞の侵入を積極的に抑制する.
  • 中線ECMとPCDを阻害すると,ipsilateralityが破壊され,PCDを誘導することで回復しました.

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Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

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Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
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結論:

  • Ipsilateralityは進化的に保存された双方向性の重要な構成要素です.
  • プログラム細胞死 (PCD) は 発達不均衡の確立と維持に 重要な役割を果たします
  • これらのメカニズムを理解することで 発達障害や進化過程の洞察が得られます