抗生物質耐性の進化に対する耐性の影響
Jiafeng Liu1, Orit Gefen1, Irine Ronin1
1Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University of Jerusalem, Jerusalem, Israel.
Science (New York, N.Y.)
|January 11, 2020
まとめ
耐性だけでなく耐性も 抗生物質耐性の進化を加速します この発見は,細菌感染症を効果的に防ぐための新しい組み合わせ治療法の開発に不可欠です.
科学分野:
- 微生物学
- 進化生物学
- 薬理学について
背景:
- 抗菌剤耐性の予防には 薬の組み合わせが標準です
- 耐性という明確な生存メカニズムが,組み合わせ治療の有効性において果たす役割は,十分に理解されていない.
研究 の 目的:
- 抗生物質の併用療法によるStaphylococcus aureusにおける耐性の進化に対する耐性の影響を調査する.
- 耐性が抵抗性の発達を促進するメカニズムを解明する.
主な方法:
- 併用治療を受けている患者のStaphylococcus aureus菌株のモニタリング
- 臨床用単離体で in vitro 進化実験を行う.
- 異なる抗生物質のクラスでの効果をテストしています.
主要な成果:
- 耐性変異は患者で急速に発生し,併用療法にもかかわらず耐性の発症に先立ちました.
- In vitro実験では,耐性が組み合わせ治療で耐性の進化を容易にすることが示されました.
- 耐性の効果は,様々な抗生物質のクラスで一貫していた.
結論:
- 耐性は,組み合わせ治療でも耐性の進化を加速させる重要な要因です.
- 薬剤耐性を効果的に予防するために,将来の併用治療戦略は,耐性を考慮する必要があります.
- 耐性メカニズムの理解は より強力な抗菌薬の設計に不可欠です
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