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Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

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P450-BM3 触媒による硫化と水酸化: 共通または2つの異なる触媒活性種?

Jian-Bo Wang, Qun Huang, Wei Peng1

  • 1State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 360015 , P. R. China.

Journal of the American Chemical Society
|January 14, 2020
PubMed
まとめ

この研究では,ヘム-FeO (化合物I) の中間物質は,P450-BM3酵素によって触媒化された硫化反応と酸化性水酸化反応の両方に重要であることが明らかになりました. この発見は 酵素処理をめぐる長年の謎を解明しました

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