悪性左心房縮と心不全の発生率における人種的差異:マルチコホート研究
Alana A Lewis1, Colby R Ayers1, Elizabeth Selvin2
1Department of Medicine, University of Texas Southwestern Medical Center, Dallas (A.A.L., C.R.A., I.N., A.P., M.H.D., J.D.B., J.A.d.L.).
Circulation
|January 15, 2020
まとめ
悪性左心房縮 (LVH) は黒人においてより一般的であり,心不全 (HF) のリスクを著しく増加させる. この高い罹患率は部分的に HFの発達における人種差を説明します
科学分野:
- 心臓病科
- 公衆衛生
- 遺伝学
背景:
- 左心室高縮 (LVH) の悪性サブフェノタイプは,心不全 (HF) のリスクの増加と関連しています.
- HFの流行における人種差異は 根本的な要因を示唆している.
研究 の 目的:
- 黒人における悪性 LVH の高い流行が,HF リスクにおける人種差異に寄与するかどうかを調査する.
- 異なる人種および性別グループにおける悪性 LVH と発症したHF の関連性を調べる.
主な方法:
- 3つの大規模なコホート研究 (ARIC,DHS,MESA) の15,710人の参加者のデータをまとめました.
- グループに分類された参加者は,ECG-LVHなし,ECG-LVHでは正常なバイオマーカーがあり,ECG-LVHでは心臓バイオマーカーが上昇した (悪性LVH).
- 10年間のフォローアップ期間におけるHF事件の評価
主要な成果:
- 黒人男性と女性の悪性 LVH の罹患率は白人男性と比べて3倍でした.
- 悪性 LVH は,人種/ 性別に関係なく,HF の 2. 8 倍の増加と関連していました.
- 黒人男性では33%,黒人女性では11%の高血圧リスクが悪性 LVH に起因する.
結論:
- 黒人における悪性 LVH の高い罹患率は,部分的にHFのリスクの増加を説明する可能性がある.
- 悪性 LVH の予防や緩和のための戦略を調査することは,HF リスクと人種差の軽減に不可欠です.
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