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Updated: Dec 30, 2025

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
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Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

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ミコバクテリアのタンパク質の宿主介のユビキチン化は免疫を抑制する

Lin Wang1, Juehui Wu1,2, Jun Li3

  • 1Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Nature
|January 17, 2020
PubMed
まとめ

Mycobacterium tuberculosisはホストのANAPC2タンパク質を使って,そのRv0222タンパク質にユビキチンを結合させ,ホストの免疫反応を抑制する. この相互作用はM. tuberculosisの毒性にとって極めて重要であり,免疫調節剤にとって新しい標的となる.

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