B細胞と三次リンパ性構造は,免疫療法反応を促進する.
Beth A Helmink1, Sangeetha M Reddy2, Jianjun Gao3
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. bhelmink@mdanderson.org.
Nature
|January 17, 2020
まとめ
T細胞だけでなくB細胞も がん治療に不可欠です 私たちの研究では B細胞のシグネチャーと 三次リンパ性構造が 免疫チェックポイントのブロック治療で 成功を予測しています
科学分野:
- 免疫学
- 腫瘍学
- 癌 研究
背景:
- 免疫チェックポイントブロック (ICB) はがん治療に変化をもたらしましたが 予測バイオマーカーと反応増強戦略は主にT細胞に焦点を当てています
- ICB治療への反応におけるB細胞などの他の免疫細胞の役割は,まだ理解されていない.
研究 の 目的:
- 免疫チェックポイントブロック (ICB) 治療に対する反応を予測し,潜在的に強化するB細胞と三次リンパ性構造の役割を調査する.
- ICB治療の有効性に関する新しいバイオマーカーを特定する.
主な方法:
- ICB治療を受けた患者の腫瘍サンプルにおける遺伝子発現を分析するために,バルクおよび単細胞RNA配列解析を行う.
- 免疫細胞とストロマ細胞の組成を評価するための計算分析 (MCPカウンター).
- ヒストロジカル評価と質量細胞測定で,B細胞の局所化と表型を調べる.
主要な成果:
- B細胞特異的な遺伝子シグネチャーは,複数のICBコホートにおける応答者対非応答者の腫瘍で最も差異的に表現された.
- B細胞は三次リンパ性構造の中で発見され,応答者はクローン拡張とB細胞のユニークな機能状態を示しました.
- ICB治療に反応した患者の腫瘍で,スイッチされた記憶B細胞が増殖した.
結論:
- B細胞は,抗腫瘍免疫とICB治療への反応において重要な役割を果たします.
- 三次リンパ性構造は,ICB治療の有効性に関連しています.
- B細胞関連のバイオマーカーと治療戦略は,がん治療の成果を改善する見込みです.
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