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Updated: Dec 30, 2025

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
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脂質ナノディスクにおけるM2マスカリン受容体-βアレスティン複合体の構造

Dean P Staus1,2, Hongli Hu3,4, Michael J Robertson3,5

  • 1Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Nature
|January 17, 2020
PubMed
まとめ

研究者らは,βアレスティン1 (βarr1) が,Gタンパク質結合受容体 (GPCRs) と,冷凍EMを用いてどのように相互作用するかを明らかにした. 受容体と脂質二層を含むこの相互作用は,受容体内化とシグナルの無敏感化にとって鍵となる.

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