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関連する概念動画

Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

3.4K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
3.4K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

3.3K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.3K
Mechanical Protein Functions01:58

Mechanical Protein Functions

5.4K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
5.4K
Two Force Member01:30

Two Force Member

1.7K
The equilibrium of a two-force body is a particular case that is often encountered in practical applications. A two-force body is a rigid body that is subjected to only two external forces. For such a body to be in equilibrium, the two forces must have the same magnitude, the same line of action, and the opposite direction.
1.7K
Machines: Problem Solving I01:22

Machines: Problem Solving I

635
A toggle clamp is a mechanical device commonly used for holding and clamping objects in various applications, such as woodworking, metalworking, and assembly operations. Consider a toggle clamp subjected to a force of 200 N at the handle. The vertical clamping force can be calculated, provided the dimensions of the toggle clamp are known.
The toggle clamp system is a machine structure consisting of movable, pin-connected multi-force members that form a stabilized system to transmit forces. The...
635
ATP Synthase: Structure01:18

ATP Synthase: Structure

14.8K
ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
14.8K

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関連する実験動画

Updated: Dec 30, 2025

A Tactile Automated Passive-Finger Stimulator TAPS
19:44

A Tactile Automated Passive-Finger Stimulator TAPS

Published on: June 3, 2009

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(機械的) 力がAT2と共にいられるように

Julio Sainz de Aja1, Carla F Kim1

  • 1Stem Cell Program, Division of Hematology/Oncology and Division of Respiratory Disease, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

Cell
|January 18, 2020
PubMed
まとめ

異症性肺線維症のアルベオラ幹細胞の損傷は 機械的な緊張を生み出し 肺の外側から内側へと 線維症を駆動する. この発見は肺疾患の進行について 新たな洞察を与えてくれます

科学分野:

  • 肺医学
  • 細胞生物学
  • 生物医学工学

背景:

  • Idiopathic pulmonary fibrosis (IPF) は,肺構造の漸進的な破壊によって特徴づけられる壊滅的な肺疾患である.
  • IPFにおける特徴的な"周辺から中心への"線維症の進行を駆動するメカニズムは,まだ完全に理解されていません.

研究 の 目的:

  • 肺繊維症における胞幹細胞の空間的調節における役割を調査する.
  • アルベオラ幹細胞によって生成される機械的な力の繊維性疾患の進行への貢献を解明する.

主な方法:

  • ウォー氏による研究 (2020) では,先進的な細胞および組織工学の技術が利用されました.
  • 肺線維症のモデルにおけるアルベオラ (AT2) 幹細胞の機械的性質と行動を調査した.

主要な成果:

  • 障害のあるアルベオラ (AT2) 幹細胞は異常な機械的緊張を引き起こすことが判明しました.
  • この機械的緊張は肺内の線維症の発展を空間的に制御することが示された.
  • この発見は幹細胞機能障害と 線維性疾患の広がりの特定のパターンを関連付けています

結論:

さらに関連する動画

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
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Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

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Ex vivo Mechanical Loading of Tendon
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Ex vivo Mechanical Loading of Tendon

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関連する実験動画

Last Updated: Dec 30, 2025

A Tactile Automated Passive-Finger Stimulator TAPS
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A Tactile Automated Passive-Finger Stimulator TAPS

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Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

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Ex vivo Mechanical Loading of Tendon
11:36

Ex vivo Mechanical Loading of Tendon

Published on: May 28, 2007

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  • 機能不全のアルベオラ幹細胞と,それらが施す機械的な力は,イディオパシー性肺線維症の進行を促す重要な要因である.
  • この研究は,肺線維症の空間的側面を理解し,潜在的にターゲットにするための新しい道を開きます.