関連する実験動画

Updated: Dec 30, 2025

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
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Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

Published on: May 22, 2018

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アドレナージックCaV1.2刺激のメカニズムは,近接プロテオミクスによって明らかになった

Guoxia Liu1, Arianne Papa2, Alexander N Katchman1

  • 1Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.

Nature
|January 24, 2020
PubMed
まとめ

研究者達は,カルシウム・チャネルだけではなく, 闘うか逃げるか反応を媒介する タンパク質Radを発見しました. タンパク質キナーゼAのリン酸化は,CaV1.2チャネルの抑制を緩和し,心臓の収縮性を増加させます.

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Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
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