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Updated: Dec 30, 2025

IridiumIII Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
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IridiumIII Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II

Published on: July 7, 2015

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インフルエンザA M2のpH感知ヒスティジンサイドチェーンにおけるイミダゾール-イミダゾール水素結合

Kumar Tekwani Movellan1, Melanie Wegstroth1, Kerstin Overkamp1

  • 1Department of NMR Based Structural Biology , Max Planck Institute for Biophysical Chemistry , Am Fassberg 11 , Göttingen 37077 , Germany.

Journal of the American Chemical Society
|January 24, 2020
PubMed
まとめ

インフルエンザA M2チャネルヒスティジン側鎖は中性状態で水素結合を形成し,ウイルスの複製に不可欠なpH依存型陽子伝導に影響を与えます. この発見は,M2チャネル機能と薬物相互作用の理解に影響を与える.

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Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps09:30

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Basicity of Heterocyclic Aromatic Amines01:25

Basicity of Heterocyclic Aromatic Amines

Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
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A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
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Molecular Geometry and Dipole Moments

The VSEPR theory can be used to determine the electron pair geometries and molecular structures as follows:
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Structure of Amines

The hybridized nitrogen atom in amines possesses a lone pair of electrons and is bound to three substituents with a bond angle of around 108°, which is less than the tetrahedral angle of 109.5°. However, the C–N–H bond angle is slightly larger at 112°, with a carbon–nitrogen bond length of 147 pm. This carbon–nitrogen bond length of of amines is longer than the carbon–oxygen bond of alcohols (143 pm) but shorter than alkanes’ carbon–carbon bond (154 pm). These aspects are...
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