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Updated: Dec 30, 2025

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
09:30

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

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広範囲にわたる転写スキャニングは,遺伝子進化の速度を調節する

Bo Xia1, Yun Yan2, Maayan Baron2

  • 1Institute for Computational Medicine, NYU Langone Health, New York, NY 10016, USA; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.

Cell
|January 25, 2020
PubMed
まとめ

転写スキャニングとして知られる 精巣内の広範囲にわたる遺伝子の活動は 男性の生殖系DNAを 損傷から保護します このプロセスは発現する遺伝子の変異率を下げ,遺伝的整合性を保ちます.

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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