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Updated: Dec 29, 2025

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
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シングル・セル・トランスクリプトミック・アトラス・オブ・プライマートの卵巣老化

Si Wang1, Yuxuan Zheng2, Jingyi Li3

  • 1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institute for Brain Disorders, Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Cell
|February 1, 2020
PubMed
まとめ

卵巣の老化と生殖能力の低下は,特に卵細胞と粒状細胞の酸化損傷と関連しています. この研究は,年齢関連の不妊症の 分子メカニズムと潜在的な治療標的を明らかにしています.

キーワード:
年老化抗酸化遺伝子粒状細胞卵細胞卵巣類人猿単細胞RNAシーケンシング

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