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Updated: Dec 29, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

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人間のカンナビノイド受容体CB2-Giシグナリング複合体の冷凍-EM構造

Changrui Xing1, Youwen Zhuang2, Ting-Hai Xu3

  • 1Department of Pharmaceutical Sciences, Computational Chemical Genomics Screen Center, School of Pharmacy, and NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA 15261, USA; Drug Discovery Institute and Departments of Computational Biology and of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Cell
|February 1, 2020
PubMed
まとめ

研究者はCB2受容体信号複合体の構造を明らかにし,WIN 55,212-2のようなアゴニストがどのように結合するかを明らかにしました. この発見は,CB1の副作用のない 痛みや炎症に対する新しい薬の設計に役立ちます.

キーワード:
カンナビノイド受容体CB2の3D構造CB2とCB1の活性化メカニズムアゴニスト結合CB2- Giシグナリング複合体CB2 アゴニストCB2 カップリングの特異性CB2 薬物発見CB2逆アゴニストクリオ・エム構造Gi カップリング 汎用性余剰エネルギー貢献

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