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Updated: Nov 24, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Published on: June 8, 2022

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カンナビノイド受容体-Gi複合構造による活性化およびシグナル伝達機構

Tian Hua1, Xiaoting Li1, Lijie Wu1

  • 1iHuman Institute, ShanghaiTech University, Shanghai 201210, China.

Cell
|February 1, 2020
PubMed
まとめ

カナビノイド受容体CB1とCB2の構造的な洞察は,多様な活性化メカニズムを明らかにします. この研究は,CB1に関連した精神活性のない痛みを和らげる選択的なCB2アゴニストの開発への道を開きます.

キーワード:
CB2-Gi についてGタンパク質結合受容体アクティベーションアロステリック調節カナビノイド受容体コレステロールクリオ・エム構造クリスタル構造サブタイプ選択性

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