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Updated: Dec 29, 2025

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
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リガンド適合バイアスは,Hsp90の表面暴露ライシンをエナチオセレクティブに変更する

Adolfo Cuesta1, Xiaobo Wan1,2, Alma L Burlingame2

  • 1Department of Cellular and Molecular Pharmacology , University of California , San Francisco , California 94158 , United States.

Journal of the American Chemical Society
|February 4, 2020
PubMed
まとめ

研究者は,共性阻害剤を用いてタンパク質を選択的に標的とする新しい戦略を開発した. 制限されたリンカーを設計することで,熱ショックタンパク質90 (Hsp90) のライシン残留物の迅速かつ特異的な修正を達成し,薬物開発の可能性を高めました.

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