核塩基 と アミノ酸 を 含む 自己 複製 する 分子 の 自発 的 な 出現
Bin Liu1, Charalampos G Pappas1, Jim Ottelé1
1Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Journal of the American Chemical Society
|February 6, 2020
まとめ
研究者はRNA-ペプチドの共進化が 自己複製分子に繋がる方法を示しています 新しい方法は,アミノ酸と核塩基からキメリックマクロサイクルを作り,単純な単位から指数関数的な成長を可能にします.
科学分野:
- 生命 研究 の 起源
- 化学生物学
- 生物化学
背景:
- アビオゲネシスの正確な条件とメカニズムは 未知のままです
- RNA-ペプチド共同進化の仮説は,アミノ酸と核塩基の間の古代のリンクを示唆し,現在の生物学的システムより前のものである.
研究 の 目的:
- 生命の起源における RNA-ペプチド共同進化の可能性を調査する
- アミノ酸と核塩基の相互作用によって 自己複製する新種の分子の生成を証明する.
主な方法:
- ダイナミック・コンビネトリアル・ケミストリーのアプローチを用いて 分子相互作用を研究した.
- アミノ酸と核塩基の両方を含む自己複製マクロサイクルを合成するための2つの戦略を開発した.
- 単一の核塩基から自己複製を開始し,前合成オリゴヌクレオチド鎖の必要性を回避した.
主要な成果:
- 指数関数的に成長できるキメリックアミノ酸/核塩基マクロサイクルを成功裏に製造した.
- 固有の構成要素の結合による 極めて特殊な環状構造の形成を証明した.
- 自己複製と共に自発的自己組み立てが観察され, オーダーされたナノ構造につながった.
結論:
- アミノ酸と核塩基の相互作用により,単純な前体から自己複製システムが生成される.
- 開発された方法は 生命の初期の出現を理解するための 新しい経路を提供します
- この研究は,プレバイオティック化学における分子複合性の形成と自己組織化についての洞察を提供します.
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