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Updated: Dec 29, 2025

Quick Fluorescent In Situ Hybridization Protocol for Xist RNA Combined with Immunofluorescence of Histone Modification in X-chromosome Inactivation
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SPENは,X不活性化のトランスクリプションと表遺伝子制御を統合する

François Dossin1, Inês Pinheiro2, Jan J Żylicz2,3

  • 1European Molecular Biology Laboratory, Director's Unit, Heidelberg, Germany.

Nature
|February 7, 2020
PubMed
まとめ

SPENタンパク質は,Xist RNAと結合し,静止装置を募集することによって,X染色体不活性化 (XCI) を開始するために不可欠です. そのSPOCドメインは,Xistと転写因子を統合して,遺伝子サイレッシングの鍵です.

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