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Updated: Dec 29, 2025

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
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Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

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段階分離は,自己ファゴソーム形成の場所を整理する

Yuko Fujioka1, Jahangir Md Alam1, Daisuke Noshiro1,2

  • 1Institute of Microbial Chemistry (BIKAKEN), Tokyo, Japan.

Nature
|February 7, 2020
PubMed
まとめ

オートファギーの前自吸体構造 (PAS) は,Atgタンパク質の液体状の凝縮物です. この相分離は 細胞の分解プロセスに不可欠な 自己消化機構を組織します

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Autophagy01:27

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An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Delivery Pathways to the Lysosome

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Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
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Maturation of Endosomes

The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
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The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
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Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
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Distribution of Cytoplasmic Content

Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
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