Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.3K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.3K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

1.8K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
1.8K
Long-term Depression01:03

Long-term Depression

3.0K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.0K
Long-term Depression01:05

Long-term Depression

32.9K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
32.9K
Forgetting01:21

Forgetting

303
Forgetting is an intrinsic aspect of human memory, characterized by the gradual loss or inaccessibility of information over time. Hermann Ebbinghaus, a pioneering psychologist, extensively studied this phenomenon and formulated the forgetting curve. This curve illustrates that memory loss occurs rapidly immediately after learning and then decelerates over time. Several mechanisms contribute to forgetting, including encoding failure, storage decay, retrieval failure, and interference.
Encoding...
303
Interference and Decay01:16

Interference and Decay

368
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
368

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

The Impact of Climate Change on the Spatial Distribution of Seven <i>Meconopsis</i> Species in China: A MaxEnt Model-Based Predictive Analysis.

Ecology and evolution·2026
Same author

Development of a multimodal large language model for early warning and diagnosis of chronic ocular GVHD.

NPJ digital medicine·2026
Same author

Steam reforming of biomass tar using the low-cost incineration bottom ash as catalyst.

Journal of environmental management·2026
Same author

Potential roles of plant metabolites and Traditional Chinese Medicine formulas in regulating glycolysis-OXPHOS plasticity in gastric precancerous lesions and gastric cancer: a critical appraisal of the evidence.

Frontiers in pharmacology·2026
Same author

Integrating multi-omics and epiphytic microbial communities to decipher the spatiotemporal dynamics of flower color dynamic regulation in <i>Hibiscus mutabilis</i>.

Frontiers in plant science·2026
Same author

The QseB/QseC two-component system modulates virulence, motility, and outer membrane vesicles biogenesis in Salmonella enteritidis.

Microbial pathogenesis·2026
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
関連記事をすべて見る

関連する実験動画

Updated: Dec 29, 2025

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology
07:41

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology

Published on: May 31, 2024

1.8K

マイクログリア媒介の忘却は,コンプリメント依存のシナプス除去による.

Chao Wang1,2, Huimin Yue1,2, Zhechun Hu1,2

  • 1Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.

Science (New York, N.Y.)
|February 8, 2020
PubMed
まとめ
この要約は機械生成です。

マイクログリアが脳内のシナプスを吸収し 記憶の喪失を引き起こします このプロセスを阻害すると,特に補完経路は,記憶喪失を防止し,エングラム細胞の接続を維持します.

さらに関連する動画

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.6K
Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester
08:10

Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester

Published on: July 7, 2015

9.0K

関連する実験動画

Last Updated: Dec 29, 2025

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology
07:41

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology

Published on: May 31, 2024

1.8K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.6K
Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester
08:10

Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester

Published on: July 7, 2015

9.0K

科学分野:

  • 神経科学
  • 免疫学
  • 記憶に関する研究

背景:

  • エングラム細胞のシナプスは 記憶の保存に不可欠です
  • 記憶喪失はこれらのシナプスの弱まりや喪失と関連しています
  • 脳の免疫細胞であるマイクログリアは シナプス可塑性に関与しています

研究 の 目的:

  • 遠隔記憶の忘却における マイクログリアの役割を調査する
  • マイクログリアが記憶の劣化に寄与するメカニズムを解明する.
  • マイクログリア媒介の忘却に 補完体の経路が関与するかどうかを判断する.

主な方法:

  • ネズミのヒポカンプにおけるシナプス成分のマイクログリアル吸収の観察.
  • マイクログリアの枯渇と マイクログリアのファゴサイトーズの抑制
  • CD55を導入し,エングラム細胞の補完経路を阻害する.
  • 記憶保持とエングラム細胞解離の評価

主要な成果:

  • 健康な成人のマウスでは,シナプス成分の微小膠質吸収が観察されました.
  • マイクログリアを枯渇させたり ファゴサイトーシスを阻害したりすることで 記憶の忘却を防ぐことができました
  • エングラム細胞の補完経路の阻害も忘却を防ぎました
  • マイクログリアはニューロゲネシスに関連した記憶の劣化と無関係な記憶の劣化の両方に関与していた.

結論:

  • マイクログリアは,補足に依存し,活動に依存した方法でシナプスを排除し,記憶の忘却につながります.
  • 遠隔記憶の忘却の鍵となるメカニズムです 遠隔記憶の忘却の鍵となるメカニズムです
  • マイクログリアの活動と補完経路をターゲットにすることで 記憶喪失と闘う戦略を提供できます