免疫グロブリンMに関する構造的な洞察
Yaxin Li1,2, Guopeng Wang3, Ningning Li2,3
1State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.
Science (New York, N.Y.)
|February 8, 2020
まとめ
この研究では,結合鎖 (J鎖) とポリマー免疫グロブリン受容体 (pIgR) と複合したImmunglobulin M (IgM) の構造が明らかにされ,IgMが免疫のためにどのように組み立てられ輸送されるかを明らかにしました.
科学分野:
- 構造生物学
- 免疫学
- 分子 機構
背景:
- 免疫グロブリンM (IgM) は,体内および粘膜の免疫に不可欠です.
- IgMの組み立てと輸送は,結合鎖 (J鎖) とポリマー免疫球体受容体 (pIgR) を含む.
- IgMの組み立てと輸送の基礎となる分子機構は,まだ十分に理解されていません.
研究 の 目的:
- IgMの組み立てと輸送の構造的基礎を明らかにする.
- IgM-Fc,J鎖,およびpIgRエクトドメインの間の分子相互作用を決定する.
主な方法:
- 複合体を視覚化するために,冷凍電子顕微鏡 (cryo-EM) が使用されました.
- ヒトのIgM-Fc領域とJ鎖とpIgRエクトドメインの構造分析
主要な成果:
- 凍結-EM構造は,不対称なIgM-Fcペンタマーと六角形,不完全な三角形を形成した.
- IgM-Fc尾部は,ペンタマー安定化のためのアミロイドのような構造を形成する.
- J鎖はIgM-FcとpIgRを橋渡しし,複合的な関与のためにpIgRの重要な構成変化を誘導する.
結論:
- この研究は,IgM-Fc,J鎖,およびpIgR複合体に関する最初の構造的洞察を提供します.
- この構造的な理解は,免疫反応におけるIgMの機能的メカニズムを解読するための基礎を提供します.
関連する概念動画
01:10Antibody Structure
65.1K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.1K
01:25Antibody Structure and Classes
8.0K
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
8.0K
01:31Immunoglobulin-like Cell Adhesion Molecules
4.1K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.1K
01:22Development of Immunocompetence
686
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
686
01:24B Cell Activation and Differentiation
15.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.7K
01:23Immunological Memory
14.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.7K