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パーキンソン 病 の 診断 と 治療 ― 概要
Melissa J Armstrong1,2, Michael S Okun1,2
1Department of Neurology, University of Florida College of Medicine, Gainesville.
JAMA
|February 12, 2020
まとめ
パーキンソン病は 何百万人にも及ぶ 常見の神経疾患で 症状や発症率は 様々です 現在の治療法では 症状は治りますが 病状の進行を止めることはできず 先進的な治療法の必要性を強調しています
科学分野:
- 神経科学
- 運動障害
- 神経変性疾患
背景:
- パーキンソン病は パーキンソン病の最も一般的な形態で 硬直さや遅さや震えなどの 運動障害が特徴です
- 世界中で600万人以上が 罹患しており 深刻な健康問題を抱えています
研究 の 目的:
- パーキンソン病の診断基準,疾患の異質性,現在の治療戦略を要約する.
- 既存の治療の症状性と 病気を修正する選択肢の欠如を強調するためです
主な方法:
- 診断は,身体検査に加えて,プロドロマ特征と運動/認知症状を含む患者の病歴に基づきます.
- ドーパミントランスポーター単光子放射コンピュータトモグラフィーは,不確実な症例の診断に役立ちます.
- 疾患の変種は,症状の表れ,進行,および薬剤への反応に基づいて特定されます.
主要な成果:
- パーキンソン病は異質性があり,軽度の運動型から拡散性悪性型までのサブタイプがあります.
- 症状治療は,ドーパミナージックおよびノンドーパミナージック剤を用いて,運動および非運動の両方の症状に焦点を当てています.
- 脳の深部刺激や レボドーパ-カルビドーパ 腸内サスペンションなどの 治療法により 合併症は治ります
結論:
- パーキンソン病は異質な疾患で 進行率は変化します
- 現在の治療は主に薬理学的および非薬理学的アプローチを用いて行われる.
- 現在,病気を修正する治療法はありませんので,総合的な症状管理と合併症に対する先進的な治療法の重要性を強調しています.
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