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Updated: May 6, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

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ペプチドエピトープと天然製品の断片を組み合わせたマクロサイクル方式

Stéphanie M Guéret1,2, Sasikala Thavam3, Rodrigo J Carbajo4

  • 1Department of Chemical Biology, AstraZeneca-Max Planck Institute Satellite Unit, Max-Planck-Institute of Molecular Physiology, 44227 Dortmund, Germany.

Journal of the American Chemical Society
|February 15, 2020
PubMed
まとめ

研究者は"ホット・ループ"タンパク質のセグメントを真似るために 自然製品にインスパイアされた構造を用いた新しい方法"PepNats"を開発しました このアプローチは,標的タンパク質の相互作用のために構造的に制約されたペプチドを生成し,新しい治療候補を生成する.

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