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Updated: Dec 28, 2025

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
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リンパ腫の誘発性変異は,象徴的なヒト自身抗体の病原性進化に起因する

Mandeep Singh1, Katherine J L Jackson1, Jing J Wang2

  • 1The Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

Cell
|February 16, 2020
PubMed
まとめ

変性B細胞はリウマチ因子自己抗体を生成し,リンパ性悪性腫瘍とのメカニズムを共有しています. これらの細胞は変異を蓄積し,血管炎で病原性自己抗体を作り出し,リンパ腫形成の前段階を明らかにします.

キーワード:
自己抗体低血圧血症リンパ腫リウマチ・ファクター単細胞オミックスソマティック変異血管炎

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