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Updated: Dec 28, 2025

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
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Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

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アンジオテンシンとバイアス型アナログは,GPCR内の構造的に異なる活性構造を誘導する

Laura M Wingler1,2, Meredith A Skiba3, Conor McMahon3

  • 1Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

Science (New York, N.Y.)
|February 22, 2020
PubMed
まとめ

Gタンパク質結合受容体 (GPCRs) のバイアスアゴニストは特定の経路を活性化します. 結晶構造は,アニオテンシンII型1受容体 (AT1R) の再配置がβ-アレスティンまたはGqタンパク質へのシグナルバイアスを決定する方法を明らかにします.

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