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Updated: Dec 28, 2025

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Ser-Thrキナーゼにおけるアロステル活性化の古代起源

Adelajda Hadzipasic1,2, Christopher Wilson1,2, Vy Nguyen1,2

  • 1Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.

Science (New York, N.Y.)
|February 22, 2020
PubMed
まとめ

オーロラAキナーゼとその活性化剤TPX2 (Xklp2を標的とするタンパク質) のアロステリック調節の進化を研究した. 古代のオートフォスフォリレーションメカニズムは安定したままで,TPX2媒介による調節はキナーゼ自体の中で進化した.

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