妊娠中の母親の腸内微生物群は,マウスの子孫の代謝表型に影響する
Ikuo Kimura1,2, Junki Miyamoto3,2, Ryuji Ohue-Kitano3,2
1Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo 183-8509, Japan. ikimura@cc.tuat.ac.jp hase-kj@pha.keio.ac.jp.
Science (New York, N.Y.)
|February 29, 2020
まとめ
母親の腸内微生物は 胚細胞の発達を導く 短鎖脂肪酸を生成することで 子孫の代謝に影響します 代謝症候群の予防に 極めて重要です
科学分野:
- 微生物学
- 発達生物学
- メタボリズム
背景:
- 腸内微生物群は病気の感受性に影響しますが,その胚性役割は不明です.
- 母親の腸内微生物群が 子孫の発達に及ぼす影響は 十分に研究されていない.
研究 の 目的:
- 母親の微生物群が子孫の胚の発達と代謝システムに与える影響を調査する.
- 母親の腸内微生物が 子孫の代謝健康を形作るメカニズムを探る
主な方法:
- 細菌がなく,従来の方法で育てられた子孫を含むマウスモデルを使用した.
- 胚の発達における短鎖脂肪酸 (SCFA) とその受容体 (GPR41,GPR43) の役割を分析した.
主要な成果:
- 母親の微生物群に由来するSCFAは,胚の神経,腸,および臓細胞の分化を調節する.
- 産後代にはメタボリックシンドロームへの感受性が高まります
- 母親の微生物の影響は 産後エネルギーホメオスタシスの確立に不可欠です
結論:
- 母親の腸内微生物群は 胚の発達過程で 子孫の代謝システムを形作る上で 重要な役割を果たします
- この研究は 妊婦の腸内環境と 代謝症候群の発達の間の 重要な関連性を示しています
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