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Updated: Dec 27, 2025

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

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ピロプトーシスにおける自動処理カスパスによるGSDMD標的化のための構造的メカニズム

Kun Wang1, Qi Sun2, Xiu Zhong1

  • 1Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, National Institute of Biological Sciences, 102206 Beijing, China; National Institute of Biological Sciences, Beijing, 102206 Beijing, China.

Cell
|February 29, 2020
PubMed
まとめ

炎症体活性化カスパース (カスパース-1, -4, -11) はガスダーミンD (GSDMD) を割って,熱死を引き起こす. この研究は,活性化カスパース-4/11が GSDMD を結合するためにユニークな水害性インターフェースを使用し,熱死を引き起こし,新しい治療標的を提供することを明らかにしています.

キーワード:
カスパースカスパース-1カスパース-11細胞死ガスダーミン炎症ゾーム生まれつきの免疫リポポリサッカリド毛穴を形成するタンパク質ピロプトーシス

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