シンガポールのSARS-CoV-2に感染した患者の流行病学的特徴と臨床経過
Barnaby Edward Young1,2,3, Sean Wei Xiang Ong1,2, Shirin Kalimuddin4,5
1National Centre for Infectious Diseases, Singapore.
JAMA
|March 4, 2020
まとめ
シンガポールの最初の18人の重症急性呼吸器症候群新型コロナウイルス2 (SARS-CoV-2) 患者はしばしば軽度の症状を示したが,一部の患者は酸素を必要とした. ロピナビル-リトナビルの治療は,この早期のSARS-CoV-2アウトブレイク研究で変化する結果と副作用を示しました.
科学分野:
- 感染症
- ウイルス学
- 公衆衛生
背景:
- 重症急性呼吸器症候群コロナウイルス2型 (SARS-CoV-2型) は2019年末に発生し,世界的なパンデミックを引き起こした.
- SARS-CoV-2の初期臨床的および疫学的特徴を理解することは,効果的な管理に不可欠です.
研究 の 目的:
- シンガポールのSARS-CoV-2に関する最初の経験について説明します.
- 初期の症例の流行病学,臨床的特徴,および管理を調査する.
主な方法:
- PCRで確認されたSARS-CoV-2感染患者18人の記述的な症例シリーズ.
- 収集されたデータには,臨床,実験室,放射線学的発見,ウイルス発散,治療結果が含まれていた.
- フォローアップは2020年2月25日まで行われました.
主要な成果:
- 大半の患者 (67%) は上部呼吸道感染を示し,33%は補充酸素を必要とし,2人は集中治療を必要とした.
- 鼻からウイルスが長時間流出する (7日以上) は,患者の83%で観察された.
- ウイルスは排泄物と血液で検出されましたが,尿では検出されていません. ロピナヴィルとリトナビルの治療は,さまざまな結果と副作用をもたらしました.
結論:
- シンガポールのSARS-CoV-2初期感染は,一般的に軽度の呼吸器疾患として提示される.
- 臨床結果は様々で,ロピナビル- リトナビルの治療は混合効果と顕著な副作用を示した.
- この研究は,SARS-CoV-2の初期臨床スペクトルと管理上の課題に関する洞察を提供します.
さらに関連する動画
関連する概念動画
Endocarditis II: Clinical Features of Infective Endocarditis
299
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
299
COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
Stages of Infection
64.5K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.5K
Single Nucleotide Polymorphisms-SNPs
17.8K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.8K
Steps in Outbreak Investigation
429
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
429
Myocarditis II: Clinical Features and Diagnostic Tests
195
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
195


